Nitric Oxide in Brain Development, Plasticity, and Disease (Progress in Brain Research)

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Tseilikman Cellular and Molecular Neurobiology. How to cite this article: Maccallini C, Amoroso R. Targeting neuronal nitric oxide synthase as a valuable strategy for the therapy of neurological disorders. Neural Regen Res ; Figure 1: Schematic representation of NO synthetic and activity pathways in physiologic conditions panel A , and pathologic conditions panel B. Both the cGMP and nitrergic signaling maintain the synaptic plasticity and cellular survival. B Both neurodegenerative and neurological disorders lead to excessive glutamatergic stimulation of NMDA receptors.

The overproduced NO is responsible for extensive protein nitrosation and nytrosilation, leading to nitrosative and oxidative stress. This, together with excessive peroxynitrite ion formation, and stimulation of the cGMP signaling, impairs neuronal metabolism and triggers apoptosis. Click here to view. Inhibitors of the neuronal NOS. Table 1: Inhibitors of neuronal nitric oxide synthase. Brain Pt 1 , — Devys, D. The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation.

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NMDA receptor C-terminal signaling in development, plasticity, and disease

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Nitric oxide signalling in the brain and its control of bodily functions

FOXP2 as a molecular window into speech and language. Trends Genet. Fromer, M. De novo mutations in schizophrenia implicate synaptic networks. Frye, R. Metabolic effects of sapropterin treatment in autism spectrum disorder: a preliminary study.

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    Gantois, I. Gao, S. Decreased NOS1 expression in the anterior cingulate cortex in depression. Cortex 23, — Garber, K. Tadalafil crosses the blood-brain barrier and reverses cognitive dysfunction in a mouse model of AD. Neuropharmacology 64, — Garthwaite, J. Concepts of neural nitric oxide-mediated transmission. Nitric oxide signaling in the central nervous system. Geschwind, D. Neuroscience in the era of functional genomics and systems biology.

    Cortical evolution: judge the brain by its cover. Neuron 80, — Goldman-Rakic, P. The prefrontal landscape: implications of functional architecture for understanding human mentation and the central executive. B Biol. Gross, C. Fragile X mental retardation protein regulates protein expression and mRNA translation of the potassium channel Kv4.

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